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Home Antibody All anti-ARNT antibodies

Anti-ARNT TRUEMAB Antibody Clone OTI1D10

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA501148 anti-ARNT (HIF1 beta) mouse monoclonal antibody, clone OTI1D10 (formerly 1D10) 100ul $325 In Stock
LC400636 ARNT HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF501148 Carrier-free (BSA/glycerol-free) ARNT mouse monoclonal antibody, clone OTI1D10 (formerly 1D10) 100ug $450 3-4 weeks
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WB(1)
IHC(2)
IF(1)

OriGene Data

ImmunogenFull length human recombinant protein of human ARNT (NP_001659) produced in HEK293T cell.
Clone NameClone OTI1D10 IsotypeIgG1
Species ReactivityHuman Concentration0.73 mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB 1:2000, IHC 1:50, IF 1:100,
Predicted MW Explanation 86.5kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT), transcript variant 1
Alternative NamebHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO
Database LinkNP_001659
Entrez Gene 405 Human
FunctionThe aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.
Related PathwayTranscription FactorsDruggable Genome Pathways in cancerRenal cell carcinoma

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ARNT (RC216724, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ARNT.
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue N93ing anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501148, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded prostate tissue within the normal limits using anti-ARNT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501148, Dilution 1:50)
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Anti-ARNT mouse monoclonal antibody (TA501148) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ARNT(RC216724).
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