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Home Antibody All anti-ARMETL1 antibodies

Anti-ARMETL1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306476
  • Rabbit Polyclonal CDNF Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC422270) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for ARMETL1 (NM_001029954)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenCDNF antibody was raised against a 9 amino acid peptide from near the carboxy terminus of human CDNF.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 2 - 4 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens cerebral dopamine neurotrophic factor (CDNF)
Alternative NameARMETL1
Database LinkNP_001025125
FunctionThe conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson’s disease. At least two isoforms of CDNF are known to exist. This antibody does not cross-react with MANF.
Related Pathway

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WB Image
Western blot analysis of CDNF in mouse brain tissue lysate with CDNF antibody at (A) 2 and (B) 4 ug/ml.
IHC Image
Immunohistochemistry of CDNF in human brain tissue with CDNF antibody at 2.5 ug/ml.

 

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