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Home Antibody All anti-ARL6IP1 antibodies

Anti-ARL6IP1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306164
  • Rabbit Polyclonal ARMER Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC414753) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for ARL6IP1 (NM_015161)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenARMER antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens ADP-ribosylation factor-like 6 interacting protein 1 (ARL6IP1)
Alternative NameAIP1; ARL6IP; ARMER; SPG61
Database LinkNP_055976
FunctionApoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA (1). Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12 (2), other caspases such as caspase-9 are also thought to be activated following ER stress (3). Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
Related Pathway

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WB Image
Western blot ana-lysis of ARMER in mouse small intestine tissue lysates with ARMER antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
IHC Image
Immunohistochemical staining of human bladder tissue using ARMER antibody at 2 ug/ml.

 

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