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Anti-APP Antibody

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SKU Description Amount Price Availability*  
TA308848 Rabbit Polyclonal antibody to beta Amyloid (amyloid beta (A4) precursor protein) 100ul $325 3-7 Days
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WB(2)
IHC(1)
IF(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 602 and 770 of beta Amyloid (Uniprot ID#P05067)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Dog, Pig, Chimpanzee, Bovine) Concentration0.2mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 87kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Dog (100%), Pig (100%), Chimpanzee (100%), Bovine (100%)

Reference Data

Target NameHomo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 7
Alternative NameAAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Database LinkNP_001129603
Entrez Gene 351 Human
Entrez Gene 11820 Mouse
Entrez Gene 403407 Dog
FunctionThis gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]
Related PathwayTransmembraneDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample(30 ug of whole cell lysate). A:Hep G2. 7.5% SDS PAGE. TA308848 diluted at 1:1500
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Sample (30 ug of whole cell lysate). A:NIH-3T3 7.5% SDS PAGE. TA308848 diluted at 1:1000.
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Immunohistochemical analysis of paraffin-embedded Tonsil, plasma cells, using beta A4 Amyloid(TA308848) antibody(10 ug/ml).
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beta Amyloid antibody [C2C3], C-term detects APP protein at cytoplasm by confocal immunofluorescent analysis. Sample: A431 cells were fixed in ice-cold MeOH for 5 min. Green: APP protein stained by beta Amyloid antibody [C2C3], C-term (TA308848) diluted a
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