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Home Antibody All anti-APOE antibodies

Anti-APOE Antibody EP1374Y

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Specifications Citations (1) Related Products Product Documents
SKU Description Amount Price Availability*  
TA300831 Rabbit Monoclonal Antibody against APOE (Clone EP1374Y) 100ul $325 In Stock
LC424959 APOE HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(2)
IHC(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-term of human apolipoprotein E was used as an immunogen.
Clone NameEP1374Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:100; IHC-P: 1:100 - 1:250; ICC/IF: 1:250 - 1:500
Predicted MW Explanation 36 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens apolipoprotein E (APOE), transcript variant 2
Alternative NameAD2; APO-E; LDLCQ5; LPG
Database LinkNP_000032
Entrez Gene 348 Human
FunctionThe apolipoproteins are family of amphipathic lipoproteins that plays a crucial role in lipid metabolism. In particular, apolipoprotein E (apo E) is a major component of high density lipoproteins (HDL) chylomicrons and very low-density lipoprotein (VLDL), which functions to remove excess cholesterol. Apo E mediates lipid metabolism and cholesterol homeostasis by binding to several hepatic lipoprotein receptors, such as low density lipoprotein receptor (LDLR) and the LDLR-related protein (1). Apo E deficiency is linked to hyperlipoproteinemia type III; a genetic disorder characterized by elevated plasma cholesterol and triglyceride levels and accelerated coronary artery disease (2). Three major isoforms of Apo E (E2, E3, E4) has been identified, with E3 being the most common in human. E4 presence has been associated to increase probability of developing late-onset form of Alzheimer disease (3).
Related PathwaySecreted ProteinStem cell - PluripotencyAdult stem cellsDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Apolipoprotein E antibody [EP1374Y]; Anti-Apolipoprotein E antibody [EP1374Y] at 1/20000 dilution + Human serum at 10 ug.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 36 kDa.Observed band size : 36 kDa.
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Figure from citation: Western Blot of ApoE protein level by using anti-ApoE antibody in human MCF7-MS. View Citation
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Immunohistochemistry (Paraffin-embedded sections) - Apolipoprotein E antibody [EP1374Y]; Immunohistochemical analysis of paraffin-embedded human normal liver using TA300831 at a dilution of 1/100-1/250.
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Immunocytochemistry/ Immunofluorescence - Apolipoprotein E antibody [EP1374Y]; Immunofluorescent staining of HepG2 cells using TA300831 at a dilution of 1/250-1/500.
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