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Anti-APOA5 Antibody 4H8H8E2
Also for APOA5 (NM_052968)
|Ni-NTA purified full length recombinant human APOA5 expressed in E. Coli strain BL21 (DE3).|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 1000
|Homo sapiens apolipoprotein A-V (APOA5), transcript variant 1|
|Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-4 (PPAR-alpha) agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.|
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HEK293T cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY APOA5 (RC211023) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APOA5.