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Home Antibody All anti-APH1A antibodies

Anti-APH1A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306378
  • Rabbit Polyclonal APH1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC421466) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for APH1A (NM_001077628)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenAPH1 antibody was raised against a 18 amino acid peptide from near the center of human APH1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens APH1A gamma secretase subunit (APH1A), transcript variant 1
Alternative Name6530402N02Rik; APH-1; APH-1A; CGI-78
Database LinkNP_001071096
FunctionAPH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gammasecretase complex which cleave the amyloid precursor protein (APP) at what are known as the gammaand gammasites and can lead to the accumulation of the Amyloid beta peptide Abetacleavage product that is associated with Alzheimer’s disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gammasecretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed. Despite its predicted molecular weight, APH1 protein often migrates at aberrant locations in SDS-PAGE.
Related Pathway
Delta-Notch Signaling Pathway

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WB Image
Western blot analysis of APH1 in human brain tissue lysate with APH1 antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of APH1 in human brain tissue with APH1 antibody at 5 ug/ml.

 

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