Home Antibody All anti-APH1A antibodies
Also for APH1A (NM_001077628)
| Peptide with sequence C-HVTDRSDARLQYG, from the internal region of the protein sequence according to NP_001071096.1; NP_057106.2.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig, Cow
||ELISA: 1:128,000. WB: 0.05-0.1µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens APH1A gamma secretase subunit (APH1A), transcript variant 1|
|6530402N02Rik; APH-1; APH-1A; CGI-78|
|APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM]. |
Delta-Notch Signaling Pathway
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TA303251 (0.05µg/ml) staining of Human Brain (Cerebral Cortex) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.