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Anti-APEX1 Antibody EPR4023
Also for APEX1 (NM_001641)
|A synthetic peptide corresponding to residues in human Ape 1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1|
|APE; APE1; APEN; APEX; APX; HAP1; REF1|
Entrez Gene 328 Human
Entrez Gene 11792 Mouse
Entrez Gene 79116 Rat
|Apurinic endonuclease (Ape 1) functions as a major DNA repair enzyme that is essential for embryogenesis and cell viability (1). It is involved in the base excision repair (BER) pathway and acts as a reduction-oxidation signaling factor to maintain transcription factors in an active reduced state (2). Ape 1 plays a critical role as a transcriptional coactivator for different transcription factors (i.e. AP-1, NF-kappaB, p53) in controlling different cellular processes such as apoptosis, proliferation, and differentiation (3). Elevated levels of Ape 1 have been found in ovarian, cervical, and prostate cancers (4).|
|Stem cell - PluripotencyTranscription FactorsDruggable Genome Base excision repair|
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Western blot - Anti-APE1 antibody [EPR4023]; All lanes : Anti-APE1 antibody [EPR4023] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : 293T cell lysate.Lane 4 : Raji cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 35 kDa.Observed band size : 36 kDa .