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Anti-APEX1 Antibody 13B8E5C2
Also for APEX1 (NM_001641)
|A fusion protein construct that contains the N-terminal region of human ACAT1.|
|human, mouse, rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:2000, IHC: 1:5000
|PBS and 0.05% sodium azide|
|Purified human APE/ref protein. (Protein A or G Sepharose)
|Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1|
|APE; APE1; APEN; APEX; APX; HAP1; REF1|
|The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme functions as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1 alpha, Pax-5, Pax-8 and other transcription factors. APE/ref-1 has also been shown to control p53 activity through redox alteration. APE is linked to apoptosis, associated with thioredoxin, and altered levels of APE/ref-1 have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.|
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HEK293T cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY APEX1 (RC201732) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APEX1.