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Anti-APCS Antibody EP1018Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300707 Rabbit Monoclonal Antibody against APCS (Clone EP1018Y) 100ul $325 In Stock
LC400617 APCS HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-term of human SAP was used as an immunogen.
Clone NameEP1018Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1e+006; IHC-P: 1:100 - 1:250
Predicted MW Explanation 25 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens amyloid P component, serum (APCS)
Alternative NameHEL-S-92n; PTX2; SAP
Database LinkNP_001630
Entrez Gene 325 Human
FunctionSerum Amyloid P (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits and this is probably due to its specific calcium-dependent binding to motifs present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits (1,2). It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T lymphocytes or B lymphocytes (3). SAP production can be induced by exposure to IL-1, IL-6 and IFN-beta. The SAP-inducing activity was neutralized by antibodies to each of the recombinant cytokines (4).
Related PathwaySecreted ProteinDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Amyloid P component antibody [EP1018Y]; Anti-Serum Amyloid P antibody [EP1018Y] at 1/1000000 dilution + Human serum membrane at 10 ug.Secondary.Goat anti-rabbit HRP labelled, at 1/2000 dilution.Predicted band size : 25 kDa.Observed band size : 25 kDa.

IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Amyloid P component antibody [EP1018Y]; Ab45151 (1:100) staining human Amyloid P component in human kidney by immunohistochemistry using paraffin embedded tissue.


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