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Anti-APCS Antibody EP1018Y
Also for APCS (NM_001639)
|A synthetic peptide corresponding to residues near the N-term of human SAP was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1e+006; IHC-P: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens amyloid P component, serum (APCS)|
|Serum Amyloid P (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits and this is probably due to its specific calcium-dependent binding to motifs present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits (1,2). It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T lymphocytes or B lymphocytes (3). SAP production can be induced by exposure to IL-1, IL-6 and IFN-beta. The SAP-inducing activity was neutralized by antibodies to each of the recombinant cytokines (4). |
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Western blot - Amyloid P component antibody [EP1018Y]; Anti-Serum Amyloid P antibody [EP1018Y] at 1/1000000 dilution + Human serum membrane at 10 µg.Secondary.Goat anti-rabbit HRP labelled, at 1/2000 dilution.Predicted band size : 25 kDa.Observed band size : 25 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Amyloid P component antibody [EP1018Y]; Ab45151 (1:100) staining human Amyloid P component in human kidney by immunohistochemistry using paraffin embedded tissue.