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Anti-APC Antibody EP701Y
|A synthetic peptide corresponding to residues near the N-terminus of human APC was used as immunogen. This antibody is predicted to detect isoform 2 based on sequence analysis.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500-1,000; IHC: 1:50-100; ICC: 50-100; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse
|Homo sapiens adenomatous polyposis coli (APC), transcript variant 3|
|BTPS2; DP2; DP2.5; DP3; GS; PPP1R46|
|This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq]. |
Wnt Signaling Pathway
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Western blot - APC antibody [EP701Y]; Anti-APC antibody [EP701Y] at 1/1000 dilution + 10 ug/ml HEK293 cell lysate.Secondary.1:2000 goat anti-rabbit HRP labeled .Observed band size : 160 kDa .Additional bands at : 250 kDa. We are unsure as to the identity of these extra bands.
Immunohistochemistry (Paraffin-embedded sections) - APC antibody [EP701Y]; ab40778 (1:50), staining human colon carcinoma by immunohistochemistry, paraffin-embedded tissue.