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Home Antibody All anti-APAF1 antibodies

Anti-APAF1 Antibody 2E10

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319611
  • Mouse Apaf-1 Monoclonal Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenA peptide corresponding to amino acids near the carboxy terminus of human Apaf1.
Clone Name2E10 Isotype
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 0.25 - 0.5 mg/ml, IHC: 0.5 ug/ml
Predicted MW Explanation 130 kDa
BufferApaf-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Purification Apaf-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Reference Data

Target NameHomo sapiens apoptotic peptidase activating factor 1 (APAF1), transcript variant 2
Alternative NameAPAF-1; CED4
Database LinkNP_001151
Entrez Gene 317 Human
Entrez Gene 11783 Mouse
Entrez Gene 78963 Rat
FunctionApaf-1 Monoclonal Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1. Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 transcript is ubiquitously expressed in human tissues.
Related PathwayDruggable Genome p53 signaling pathwayApoptosisAlzheimer's diseaseParkinson's diseaseAmyotrophic lateral sclerosis (ALS)Huntington's diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Apaf1 in K562 cell lysate with Apaf1 antibody at (A) 0.25 and (B) 0.5 mg/mL.
IHC Image
Immunohistochemistry of Apaf1 in K562 cells with Apaf1 antibody at 0.5 ug/mL.

 

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