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Home Antibody All anti-ANTXR1 antibodies

Anti-ANTXR1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306121
  • Rabbit Polyclonal ATR Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC413252) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for ANTXR1 (NM_018153)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenATR antibody was raised against a peptide corresponding to 13 amino acids near the center of human ATR.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens anthrax toxin receptor 1 (ANTXR1), transcript variant 3
Alternative NameATR; GAPO; TEM8
Database LinkNP_060623
Entrez Gene 84168 Human
Entrez Gene 69538 Mouse
Entrez Gene 362393 Rat
FunctionThe Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8) (1). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin (2). Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF) (3). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis (4).
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ATR in HepG2 cell lysates with ATR antibody (IN) at (A) 0.5, (B) 1, and (C) 2 ug/ml.
IHC Image
Immunohistochemical staining of human brain tissue using ATR antibody at 2 ug/ml.

 

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