Home Antibody All anti-ANP32A antibodies
Also for ANP32A (NM_006305)
|PHAP antibody was raised with a synthetic peptide corresponding to amino acids at amino terminus of human PHAP.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, IHC: 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A)|
|C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1; PHAPI; PP32|
|Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis (1). PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.|
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Western blot analysis of PHAP expression in human Raji cell lysate with PHAP antibody at 1 ug/mL. The wide and strong band below PHAP III is a doublelet composed of PHAP I (upper) and PHAP I2a (lower).
Immunocytochemistry of PHAP in Raji cells with PHAP antibody at 1 ug/mL.