Home Antibody All anti-ANAPC7 antibodies
Anti-ANAPC7 Antibody Polyclonal
Also for ANAPC7 (NM_016238)
|APC7 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human APC7.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IF: 20 ug/ml
|APC7 Antibody is supplied in PBS containing 0.02% sodium azide.|
|APC7 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens anaphase promoting complex subunit 7 (ANAPC7), transcript variant 1|
Entrez Gene 51434 Human
Entrez Gene 56317 Mouse
Entrez Gene 304490 Rat
|APC7 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC7 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC7 is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with various transcription coactivators.|
|Druggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation|
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Western blot analysis of APC7 in rat kidney tissue lysate with APC7 antibody at (A) 1 and (B) 2 ug/mL.
Immunofluorescence of APC7 in rat kidney tissue with APC7 antibody at 20 ug/mL.