Home Antibody All anti-ANAPC11 antibodies
Anti-ANAPC11 Antibody Polyclonal
Also for ANAPC11 (NM_001002244)
|APC11 antibody was raised against an 18 amino acid synthetic peptide near the center of human APC11.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IF: 20 ug/ml
|APC11 Antibody is supplied in PBS containing 0.02% sodium azide.|
|APC11 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens anaphase promoting complex subunit 11 (ANAPC11), transcript variant 1|
|APC11; Apc11p; HSPC214|
|APC11 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC11 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC11, together with APC2 and Ubc4, form the minimal APC ubiquitin ligase module.|
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Western blot analysis of APC11 in 3T3 cell tissue lysate with APC11 antibody at (A) 1 and (B) 2 ug/mL.