Home Antibody All anti-ANAPC10 antibodies
Anti-ANAPC10 Antibody Polyclonal
Also for ANAPC10 (NM_014885)
|APC10 antibody was raised against a 16 amino acid synthetic peptide near the center of human APC10.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|APC10 Antibody is supplied in PBS containing 0.02% sodium azide.|
|APC10 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens anaphase promoting complex subunit 10 (ANAPC10), transcript variant 2|
Entrez Gene 10393 Human
Entrez Gene 68999 Mouse
Entrez Gene 361389 Rat
|APC10 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. It has been suggested that APC10 plays a role to regulate the binding of specific substrates to the APC/C complex, similar to that of coactivators.|
|Druggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation|
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Western blot analysis of APC10 in mouse heart tissue lysate with APC10 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of APC10 in mouse heart tissue with APC10 antibody at 5 ug/mL.
Immunofluorescence of APC10 in mouse heart tissue with APC10 antibody at 20 ug/mL.