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Home Antibody All anti-ANAPC1 antibodies

Anti-ANAPC1 PHOSPHO Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319499 Rabbit polyclonal APC1 phospho S355 antibody (Phospho-specific) 100ug $325 3-7 Days
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OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 351-359 of Human Apc1 protein.
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, dog, rat, bovine Concentration1.0 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:10,000 - 1:120,000, WB: 1:200 - 1:2,000, IP: 1:100
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note APC1 (also known as Anaphase promoting complex subunit 1, Cyclosome subunit 1, Protein Tsg24, Mitotic checkpoint regulator and ANAPC1) is 1 of at least 11 subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.

Reference Data

Target NameHomo sapiens anaphase promoting complex subunit 1 (ANAPC1)
Alternative NameAPC1; MCPR; TSG24
Database LinkNP_073153
Entrez Gene 64682 Human
Entrez Gene 17222 Mouse
Entrez Gene 311412 Rat
Entrez Gene 475750 Dog
Related PathwayStem cell - PluripotencyDruggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
WB using Anti-APC1 pS355 antibody shows detection of a band ~215 kDa corresponding to phosphorylated human APC1 (arrowhead). Lane 1:lysate from asynchronous cells. Lane 2: lysate from cells treated with thymidine to synchronize cells at the G1/S boundary. Lane 3:lysate from cells treated with nocodazole to synchronize cells at the M phase. Phosphorylated APC1 is mostly present only in cell preparations arrested at cell division. Primary antibody was used at 1:500.


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