EGFR Mouse Monoclonal Antibody [Clone ID: B1D8]

CAT#: AM50265PU-T

EGFR mouse monoclonal antibody, clone B1D8, Purified

Size: 20 ug 100 ug


USD 293.00

2 Weeks*

Size
    • 20 ug

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Specifications

Product Data
Clone Name B1D8
Applications FC, IP
Recommended Dilution Affinity Purification (For coupling, order Antibody without BSA).
Blocks Ligand-induced Activation of EGFR. 
Inhibits Proliferation of A431 Cells (Order Antibody without Sodium Azide).
Arrests Tumor Growth in vivo (Order Ab without BSA and Azide). 
Immunoprecipitation: 1-2 µg/500 µg protein lysate. 
Flow Cytometry: 0.5-1 µg/million cells.
Positive Control: A431 cells, Breast or Bladder cancer
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Microsomes from A431 cells.
Specificity This antibody reacts with the extracellular domain of EGFR and blocks the EGF/TGFα−induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.
Cellular Localization: Cell surface.
Formulation 10mM PBS
State: Purified
State: Liquid purified IgG fraction from Bioreactor Concentrate
Stabilizer: 0.05% BSA
Preservative: 0.05% Sodium Azide
Concentration lot specific
Purification Protein A/G Chromatography
Conjugation Unconjugated
Storage Store undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~170 kDa (wild type) and ~145 kDa (vIII variant)
Background EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Synonyms Epidermal growth factor receptor, EGF Receptor, erbB-1, c-ErbB-1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.