EGFR Mouse Monoclonal Antibody [Clone ID: 2E9]

CAT#: AM32394PU-N

EGFR mouse monoclonal antibody, clone 2E9, Purified


USD 300.00

2 Weeks*

Size
    • 1 ml

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Specifications

Product Data
Clone Name 2E9
Applications EM, IF, IHC, IP
Recommended Dilution Immunoprecipitation.
Immunoflourescence (1/25-1/100).
Electron Microscopy.
Immunogold Labeling. 
Immunohistochemistry on Frozen Sections (1/25). 
Immunohistochemistry on Paraffin Sections. 
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Specificity This antibody clone 2E9 reacts with a protein determinant of the extra cellular domain of the Human EGFR, and does not cross react with EGFR from Murine cells.
Shows binding competition with EGF.
The antibody also reacts in Immunoprecipitation with the functional EFR protein-tyrosine kinase complex.  
The antibody has no agonistic properties, but competes efficiently with EGF for binding to the receptor.

Formulation PBS
State: Purified
State: Liquid purified IgG fraction
Stabilizer: 1% BSA
Preservative: 0.09% Sodium Azide
Concentration lot specific
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
Synonyms Epidermal growth factor receptor, EGF Receptor, erbB-1, c-ErbB-1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.