EGFR Mouse Monoclonal Antibody [Clone ID: 51CT78.40.5]
Other products for "EGFR"
Specifications
Product Data | |
Clone Name | 51CT78.40.5 |
Applications | WB |
Recommended Dilution | ELISA: 1/4000. Western blotting: 1/2000. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Purified His-tagged EGFR protein( Fragment). |
Specificity | This antibody is specific to EGFR. |
Formulation | State: Ascites State: Ascites containing 0.09% (W/V) Sodium Azide as preservative. |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | epidermal growth factor receptor |
Database Link | |
Background | EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. A prototype member of the type 1 receptor tyrosine kinases, EGFR is encoded by the cellular oncogene cerbB1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma. |
Synonyms | Epidermal growth factor receptor, EGF Receptor, erbB-1, c-ErbB-1 |
Reference Data |
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