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Home Antibody All anti-ALDH2 antibodies

Anti-ALDH2 TRUEMAB Antibody clone 4H2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (1) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500615
  • ALDH2 mouse monoclonal antibody, clone 4H2
100ul $379 In Stock
CF500615
  • Carrier-free (BSA/glycerol-free) ALDH2 mouse monoclonal antibody, clone 4H2
100ug $450 3-4 weeks
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IF(2)
FC(1)
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Also for ALDH2 (NM_000690)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human ALDH2 (NP_000681) produced in HEK293T cell.
Clone Nameclone 4H2 IsotypeIgG3
Species ReactivityHuman Concentration0.60mg/ml
Guaranteed Application *IF, FC Suggested DilutionsIF 1:50~100, FLOW 1:100,
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 1
Alternative NameALDH-E2; ALDHI; ALDM
Database LinkNP_000681
FunctionThis protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Related Pathway

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IF Image
Anti-ALDH2 mouse monoclonal antibody (TA500615) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ALDH2(RC200505).
IF Image
Immunofluorescent staining of HepG2 cells using anti-ALDH2 mouse monoclonal antibody (TA500615).
FC Image
HEK293T cells transfected with either RC200505 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-ALDH2 antibody(TA500615), and then analyzed by flow cytometry.

 

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