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Home Antibody All anti-ALDH2 antibodies

Anti-ALDH2 Antibody EPR4493

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307676
  • Rabbit monoclonal antibody against Aldh2(clone EPR4493)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400231) , 20ug
100ul 325 3-7 Days
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WB(2)
IHC(1)
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Also for ALDH2 (NM_000690)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Aldh2 was used as an immunogen.
Clone NameEPR4493 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 1
Alternative NameALDH-E2; ALDHI; ALDM
Database LinkNP_000681
FunctionAldh2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. Aldh2 encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix (1).
Related Pathway

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WB Image
Western blot - ALDH2 antibody [EPR4493]; All lanes : Anti-ALDH2 antibody [EPR4493] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : A549 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 56 kDa.
WB Image
Western blot - ALDH2 antibody [EPR4493]; All lanes : Anti-ALDH2 antibody [EPR4493] at 1/1000 dilution.Lane 1 : Mouse liver lysate.Lane 2 : Rat liver lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 56 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ALDH2 antibody [EPR4493]; TA307676 at 1/50 dilution, staining ALDH2 in paraffin-embedded Human colon tissue

 

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