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Home Antibody All anti-AKT2 antibodies

Anti-AKT2 Antibody N/A

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326431
  • Rabbit polyclonal Akt2 (PKB beta) Antibody
400µl $325 3-7 Days
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WB(1)
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Also for AKT2 (NM_001626)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA five residue synthetic peptide based on the human Akt2, coupled to KLH
Clone NameN/A IsotypeN/A
Species ReactivityHuman, Mouse, Rat, Bovine, Chicken, Dog, Guinea Pig, Hamster, Monkey, Pig, Rabbit, Sheep, Xenopus. Concentration0.25mg/mL
Guaranteed Application *WB Suggested Dilutions1:3000 dilution was sufficient for detection of PKBß in 20ug of HeLa cell lysate by ECL immunoblot analysis.
BufferTBS, 50% glycerol, 0.09% sodium azide
Purification Affinity Purified
Note Detects a 65kDa protein, corresponding to the molecular mass of Akt2 PKBß on SDS PAGE immunoblots. Does not react with PKBa (Akt1) or PKB? (Akt3).

Reference Data

Target NameHomo sapiens v-akt murine thymoma viral oncogene homolog 2 (AKT2), transcript variant 1
Alternative NameHIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA
Database LinkNP_001617
FunctionProtein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises three highly homologous members known as PKB alpha (Akt1), PKB beta (Akt2) and PKB gamma (Akt3). PKB/Akt is a growth-factor-regulated protein kinase which contains a Pleckstrin Homology (PH) domain which might be important for dimerization of the kinase. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1) and PDK2 . Myelin basic protein and histone H2B are in vitro substrates for PKB, while glycogen synthase kinase-3 has been implicated as a physiological target . Key roles for this enzyme can be found in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration .
Related Pathway
Focal Adhesion
Hemostasis
Jak-STAT signaling pathway
MAPK signaling pathway
Signaling by GPCR
Toll-like receptor signaling pathway

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WB Image
Western blot analysis of AKT2 (PKBbeta) in cell line mix using a 1:1000 dilution of the antibody

 

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