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Anti-AK1 GAT Antibody Polyclonal
Generated by Genomic Immunization
|DNA immunization. This antibody is specific for the C Terminus Region of the target protein.|
|Human , Dog , Monkey , Mouse
|WB, ELISA, IHC
|| WB 1:5000, IHC 1:150,ELISA 1:100-1:2000
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens adenylate kinase 1 (AK1)|
Entrez Gene 203 Human
Entrez Gene 11636 Mouse
Entrez Gene 706338 Monkey
Entrez Gene 480712 Dog
|Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme.|
|Druggable Genome Purine metabolismMetabolic pathways|
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-AK1 polyclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-AK1 rabbit polyclonal antibody. (TA590022)
Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-AK1 rabbit polyclonal antibody. (TA590022)
Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-AK1 rabbit polyclonal antibody. (TA590022)