Home Antibody All anti-AIRE antibodies
Also for AIRE (NM_000383)
| Peptide with sequence C-KAKPPKKPESSAEQ, from the internal region of the protein sequence according to NP_000374.1; NP_000649.1.|
|Test: Human, Mouse. Expected from seq similarity: Human, Rat, Pig, Cow
||ELISA: 1:64,000. WB: 0.3-1µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
| Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
|Homo sapiens autoimmune regulator (AIRE)|
|AIRE1; APECED; APS1; APSI; PGA1|
Entrez Gene 326 Human
Entrez Gene 11634 Mouse
Entrez Gene 294328 Rat
|This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). [provided by RefSeq]. |
|Druggable Genome Ubiquitin mediated proteolysisPrimary immunodeficiency|
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TA303185 (0.3µg/ml) staining of human spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.