Home Antibody All anti-AIFM3 antibodies
Also for AIFM3 (NM_001018060)
|AIFM3 antibody was raised against a 16 amino acid peptide from near the center of human AIFM3.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens apoptosis-inducing factor, mitochondrion-associated, 3 (AIFM3), transcript variant 2|
Entrez Gene 150209 Human
Entrez Gene 72168 Mouse
Entrez Gene 303786 Rat
|Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.|
|Druggable Genome |
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Western blot analysis of AIFM3 in human brain tissue lysate with AIFM3 antibody at (A) 1 and (B) 2 µg/ml.