Home Antibody All anti-AIFM1 antibodies
Also for AIFM1 (NM_001130846)
|AIF antibody was raised against a peptide corresponding to amino acids near the amino terminus of mature human AIF.|
||ELISA, WB: 1 ug/ml, ICC: 2 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified
|Homo sapiens apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), transcript variant 4|
|AIF; CMT2D; CMTX4; COWCK; COXPD6; NADMR; NAMSD; PDCD8|
|Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins (1). A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF) (2). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection. AIF is highly conserved between human and mouse and widely expressed (2).|
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Western blot analysis of AIF in K562 cell lysate with AIF antibody at 1 ug/mL.
Immunocytochemistry of AIF in Jurkat cells with AIF antibody at 2 ug/mL.