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Anti-AGT Antibody EPR2931
|A synthetic peptide corresponding to residues in human Angiotensinogen was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (AGT)|
|Angiotensinogen is a precursor of angiotensin-1 and a member of the serpin family, expressed by the liver and secreted in plasma. Angiotensinogen contains angiotensin-1, 2, and 3. In response to lowered blood pressure, remin cleaves angiotensinogen and produce angiotensin-1 (1). Angiotensin-converting enzyme (ACE) further removes a dipeptide to produce the physiologically active peptide angiotensin-2. Angiotensin-2 is involved in regulating mineral balance and volume of body fluids, while angiotensin-3 stimulates aldosterone release (2). In humans, angiotensinogen is 118 amino acids long, but its size varies between species. Defects in angiotensinogen have been linked to renal tubular dygenesis (RTD) and susceptibility to essential hypertension (3).|
Signaling by GPCR
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Western blot - Angiotensinogen antibody [EPR2931]; All lanes : Anti-Angiotensinogen antibody [EPR2931] at 1/1000 dilution.Lane 1 : Human fetal artery lysate.Lane 2 : Human fetal heart lysate.Lane 3 : Human fetal liver lysate.Lane 4 : HepG2 lysate.Lane 5 : 293T lysate.Lane 6 : Human plasma lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 53 kDa.
Immunocytochemistry/ Immunofluorescence - Angiotensinogen antibody [EPR2931]; ab108334, at 1/100 dilution, staining Angiotensinogen in HepG2 cells by Immunofluorescence.