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Anti-AGT Antibody EPR2931


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Angiotensinogen(clone EPR2931)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400005) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Angiotensinogen was used as an immunogen.
Clone NameEPR2931 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 53 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (AGT)
Alternative NameANHU; SERPINA8
Database LinkNP_000020
Entrez Gene 183 Human
Entrez Gene 11606 Mouse
Entrez Gene 24179 Rat
FunctionAngiotensinogen is a precursor of angiotensin-1 and a member of the serpin family, expressed by the liver and secreted in plasma. Angiotensinogen contains angiotensin-1, 2, and 3. In response to lowered blood pressure, remin cleaves angiotensinogen and produce angiotensin-1 (1). Angiotensin-converting enzyme (ACE) further removes a dipeptide to produce the physiologically active peptide angiotensin-2. Angiotensin-2 is involved in regulating mineral balance and volume of body fluids, while angiotensin-3 stimulates aldosterone release (2). In humans, angiotensinogen is 118 amino acids long, but its size varies between species. Defects in angiotensinogen have been linked to renal tubular dygenesis (RTD) and susceptibility to essential hypertension (3).
Related PathwaySecreted ProteinDruggable Genome Renin-angiotensin system

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Western blot - Angiotensinogen antibody [EPR2931]; All lanes : Anti-Angiotensinogen antibody [EPR2931] at 1/1000 dilution.Lane 1 : Human fetal artery lysate.Lane 2 : Human fetal heart lysate.Lane 3 : Human fetal liver lysate.Lane 4 : HepG2 lysate.Lane 5 : 293T lysate.Lane 6 : Human plasma lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 53 kDa.
Immunocytochemistry/ Immunofluorescence - Angiotensinogen antibody [EPR2931]; TA307762, at 1/100 dilution, staining Angiotensinogen in HepG2 cells by Immunofluorescence.


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