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Anti-AFP Antibody EP1016Y
|A synthetic peptide corresponding to residues near the N-term of human AFP was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500000; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-Fr or IHC-P.
|Homo sapiens alpha-fetoprotein (AFP)|
Entrez Gene 174 Human
|Alpha-fetoprotein (AFP) is a serum glycoprotein protein produced in the liver or yolk sac of fetal staged mammals. AFP synthesis is minimal after birth and trace amount is expressed in the adult liver (1). AFP gene expression is regulated by the interactions between steroid hormone receptors and transcriptional factors in separate signal transduction pathways (2). AFP functions as a binding and transporting ligand and cell growth regulator. Elevated expression level of AFP has been implicated in colorectal, ovarian, pancreatic, testicular, and certain liver cancers. High levels of AFP are also seen in some diseases such as hepatitis and colitis. AFP is used as a screening marker for fetal abnormalities in pregnant women such as Down syndrome. Recently, AFP has been introduced as an anti-cancer drugs-ligand carrier, transporting drugs to target tumor cells, increasing anti-tumor efficiency (3). |
|Secreted ProteinDruggable Genome |
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Western blot - alpha 1 Fetoprotein antibody [EP1016Y]; Anti-alpha 1 Fetoprotein [EP1016Y] antibody at 1/500000 dilution + HepG2 cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 69 kDa.Observed band size : 69 kDa.