Home Antibody All anti-ADIPOQ antibodies
Also for ADIPOQ (NM_001177800)
|Adiponectin antibody was raised against a 15 amino acid peptide from near the carboxy-terminus of human adiponectin.|
|Human, Mouse, Rat
||WB: 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), transcript variant 1|
|ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28|
Entrez Gene 9370 Human
Entrez Gene 11450 Mouse
Entrez Gene 246253 Rat
|Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-?-related proteins (CTRPs) 1-7 (2). Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes (3). These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene (4). It is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases (5).|
|Secreted ProteinDruggable Genome PPAR signaling pathwayAdipocytokine signaling pathwayType II diabetes mellitus|
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Western blot analysis of adiponectin in HL60 cell lysate with adiponectin antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemistry of adiponectin in rat brain tissue with adiponectin antibody at 10 ug/ml.