Home Antibody All anti-ACVR1 antibodies
Also for ACVR1 (NM_001105)
|ACVR1C antibody was raised against a 15 amino acid peptide near the amino terminus of the human ACVR1C.|
|Human, Mouse, Rat
||WB: 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens activin A receptor, type I (ACVR1), transcript variant 1|
|ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI|
|Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1B.|
Cytokine-cytokine receptor interaction
TGF Beta Signaling Pathway
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Western blot analysis of ACVR1C in human placenta tissue lysate with ACVR1C antibody at (A) 1 and (B) 2 µg/ml.