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Anti-ACTN3 Antibody EPR2532
Also for ACTN3 (NM_001104)
|A synthetic peptide corresponding to residues in human Alpha-Actinin 3 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens actinin, alpha 3 (gene/pseudogene) (ACTN3), transcript variant 1, coding|
Entrez Gene 89 Human
Entrez Gene 11474 Mouse
Entrez Gene 171009 Rat
|The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin, ACTN2 and ACTN3, are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibers, while ACTN3 expression is restricted to a subset of type 2 fibers. Absence of alpha-actinin-3 is not associated with an obvious disease phenotype, raising the possibility that ACTN3 is functionally redundant in humans, and that alpha-actinin-2 is able to compensate for alpha-actinin-3 deficiency (1). Alpha-Actinin-3 is specifically expressed in fast-twitch myofibers responsible for generating force at high velocity. The absence of a disease phenotype secondary to alpha-actinin-3 deficiency is likely due to compensation by the homologous protein, alpha-actinin-2. However, the high degree of evolutionary conservation of ACTN3 suggests function(s) independent of ACTN2. Highly significant associations between ACTN3 genotype and athletic performance have been demonstrated in both male and female athletes.|
| Focal adhesionAdherens junctionTight junctionLeukocyte transendothelial migrationRegulation of actin cytoskeletonSystemic lupus erythematosusMore Pathways >> |
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Western blot - ACTN3 antibody [EPR2532]; All lanes : Anti-ACTN3 antibody [EPR2532] at 1/1000 dilution.Lane 1 : Human skeletal muscle lysate.Lane 2 : Mouse skeletal muscle lysate.Lane 3 : Rat skeletal muscle lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 103 kDa.