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Anti-ACTN3 Antibody EPR2532


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Alpha-Actinin 3(clone EPR2532)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Alpha-Actinin 3 was used as an immunogen.
Clone NameEPR2532 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 103 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens actinin, alpha 3 (gene/pseudogene) (ACTN3), transcript variant 1, coding
Alternative NameMGC117002; MGC117005
Database LinkNP_001095
Entrez Gene 89 Human
Entrez Gene 11474 Mouse
Entrez Gene 171009 Rat
FunctionThe alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin, ACTN2 and ACTN3, are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibers, while ACTN3 expression is restricted to a subset of type 2 fibers. Absence of alpha-actinin-3 is not associated with an obvious disease phenotype, raising the possibility that ACTN3 is functionally redundant in humans, and that alpha-actinin-2 is able to compensate for alpha-actinin-3 deficiency (1). Alpha-Actinin-3 is specifically expressed in fast-twitch myofibers responsible for generating force at high velocity. The absence of a disease phenotype secondary to alpha-actinin-3 deficiency is likely due to compensation by the homologous protein, alpha-actinin-2. However, the high degree of evolutionary conservation of ACTN3 suggests function(s) independent of ACTN2. Highly significant associations between ACTN3 genotype and athletic performance have been demonstrated in both male and female athletes.
Related Pathway Focal adhesionAdherens junctionTight junctionLeukocyte transendothelial migrationRegulation of actin cytoskeletonSystemic lupus erythematosusMore Pathways >>

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Western blot - ACTN3 antibody [EPR2532]; All lanes : Anti-ACTN3 antibody [EPR2532] at 1/1000 dilution.Lane 1 : Human skeletal muscle lysate.Lane 2 : Mouse skeletal muscle lysate.Lane 3 : Rat skeletal muscle lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 103 kDa.


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