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Anti-ACO1 Antibody EPR7225


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against ACO1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400799) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human ACO1 was used as an immunogen.
Clone NameEPR7225 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IF Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
Predicted MW Explanation 98 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens aconitase 1, soluble (ACO1), transcript variant 2
Alternative NameACONS; HEL60; IREB1; IREBP; IREBP1; IRP1
Database LinkNP_002188
Entrez Gene 48 Human
Entrez Gene 11428 Mouse
Entrez Gene 50655 Rat
FunctionAconitase 1, also known as iron regulatory element binding protein 1 (IREB1) or ACO1, is a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. ACO1 was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes (1).
Related PathwayDruggable Genome Citrate cycle (TCA cycle)Glyoxylate and dicarboxylate metabolismMetabolic pathways

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Western blot - Anti-Aconitase 1 antibody [EPR7225]; All lanes : Anti-Aconitase 1 antibody [EPR7225] at 1/1000 dilution.Lane 1 : Human thyroid lysate.Lane 2 : HeLa cell lysate.Lane 3 : Human fetal kidney lysate.Lane 4 : HepG2 cell lysate.Lane 5 : T.T. cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 98 kDa.
Other-Anti-Aconitase 1 antibody [EPR7225](TA310167); Equilibrium disassociation constant (KD)..
Immunocytochemistry/ Immunofluorescence - Anti-Aconitase 1 antibody [EPR7225]; TA310167 at 1/100 dilution staining Aconitase 1 in HeLa cells by immunofluorescence.


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