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Home Antibody All anti-ACLY antibodies

Anti-ACLY Antibody EP828Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300735
  • Rabbit Monoclonal Antibody against ACLY (Clone EP828Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC420122) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for ACLY (NM_001096)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues of human ATP citrate lyase was used as immunogen.
Clone NameEP828Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:5000; IP: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens ATP citrate lyase (ACLY), transcript variant 1
Alternative NameACL; ATPCL; CLATP
Database LinkNP_001087
Entrez Gene 47 Human
Entrez Gene 104112 Mouse
Entrez Gene 24159 Rat
FunctionATP citrate lyase (ACL) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of four identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. One of these products, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. NDPK has been found to phosphorylate ACL and insulin to increase phosphorylation of ACL (2).
Related PathwayDruggable Genome Citrate cycle (TCA cycle)Metabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - ATP citrate lyase (phospho S455) antibody [EP828Y]; All lanes : Anti-ATP citrate lyase (phospho S455) antibody [EP828Y] at 1/5000 dilution.Lane 1 : Untreated 3T3 cell lysates.Lane 2 : Insulin treated 3T3 cell lysates.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Observed band size : 125 kDa .

 

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