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Home Antibody All anti-ACE2 antibodies

Anti-ACE2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306146
  • Rabbit Polyclonal ACE2 Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for ACE2 (NM_021804)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens angiotensin I converting enzyme 2 (ACE2)
Alternative NameACEH
Database LinkNP_068576
Entrez Gene 59272 Human
Entrez Gene 70008 Mouse
FunctionAngiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology (1-2). In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus (3). The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function (4).
Related PathwaySecreted ProteinTransmembraneDruggable Genome Renin-angiotensin system

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ACE2 in human kidney lysate with ACE2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemical staining of human kidney tissue using ACE2 antibody at 2 ug/ml.

 

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