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Anti-ACE Antibody EPR2757
|A synthetic peptide corresponding to residues on the C-terminus of human ACE was used as an immunogen.|
||Tissue culture supernatant
|Mouse, Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500 - 1:1000; IHC-P: 1:100 - 1:250; FC: 1:30
|Does not react with Rat. Is unsuitable for ICC or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for ICC or IP.
|Homo sapiens angiotensin I converting enzyme (ACE), transcript variant 1|
|ACE1; CD143; DCP; DCP1; ICH; MVCD3|
Entrez Gene 1636 Human
Entrez Gene 11421 Mouse
|This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined. [provided by RefSeq]. |
|Secreted ProteinES Cell Differentiation/IPSTransmembraneProteaseDruggable Genome Renin-angiotensin systemHypertrophic cardiomyopathy (HCM)|
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Western blot - Angiotensin Converting Enzyme 1 antibody [EPR2757]; All lanes : Anti-Angiotensin Converting Enzyme 1 antibody [EPR2757] at 1/1000 dilution.Lane 1 : fetal kidney lysate.Lane 2 : fetal heart lysate.Lane 3 : fetal lung lysate.Lysates/proteins at 10 ug per lane.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 150 kDa.Observed band size : 195 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Angiotensin Converting Enzyme 1 antibody [EPR2757]; TA303478 at 1/100 dilution staining Angiotensin Converting Enzyme 1 in human kidney by Immunohistochemistry, Paraffin-embedded tissue.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Angiotensin Converting Enzyme 1 antibody [EPR2757]; TA303478 at 1/100 dilution staining Angiotensin Converting Enzyme 1 in human spleen by Immunohistochemistry, Paraffin-embedded tissue. Note positive staining of endothelial cells.