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Anti-ACACA Phospho Antibody EP1885Y
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Also for ACACA (NM_198834)
|A phospho specific peptide corresponding to residues surrounding serine 79 of human ACC1 was used as an immunogen. This antibody detects ACC1 phosphorylated at serine 79.|
||WB: 1:5000; ICC: 1:100 - 250
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens acetyl-CoA carboxylase alpha (ACACA), transcript variant 1|
|ACAC; ACACAD; ACC; ACC1; ACCA|
|Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq]. |
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Western blot analysis on A431 cell lysates using anti-Phospho-ACC1 (pS79) RabMAb (TA303375), 1:10,000 dilution. Cells were either (A) untreated (B) treated with LP