Home Antibody All anti-ABCC8 antibodies
Anti-ABCC8 GAT Antibody Polyclonal
Generated by Genomic Immunization
Also for ABCC8 (NM_000352)
|DNA immunization. This antibody is specific for the Middle Region of the target protein.|
||ELISA: 1:100-1:2000; IHC: 1:500
|20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
|This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
|Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (ABCC8), transcript variant 2|
|ABC36; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; SUR1delta2; TNDM2|
Entrez Gene 6833 Human
|The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.|
|TransmembraneDruggable Genome ABC transportersType II diabetes mellitus|
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Immunohistochemistry: SUR1 Antibody - Strong membranous staining pattern observed in colo-rectal cancers by immunohistochemistry. Image is provided courtesy of the Swedish Human Proteome Resource (HPR) Center.
Immunohistochemistry: SUR1 Antibody - IHC using anti ABCC8 SEQer antibody
Immunohistochemistry: SUR1 Antibody - Most normal tissues exhibited moderate to strong cytoplasmic expression. Membranous staining pattern was seen in the intestinal tissues. Strong cytoplasmic immunoreactivity was observed in salivary gland, exocrine pancreas, skeletal muscle and non-follicle cells of lymph node. Purkinje cells and adrenal cortical cells demonstrated strong nuclear positivity. Malignant tissues generally displayed weak to moderate cytoplasmic expression. Strong membranous staining pattern was observed in colo-rectal cancers. Nuclear staining was mainly seen in non-Hodgkin's lymphomas, urothelial cancers and malignant gliomas. Image and statement courtesy of the Human Protein Atlas (HPA).
Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.