Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1)
Synonyms:
ABC-1; ABC1; CERP; HDLDT1; TGD
Immunogen
A phospho specific peptide corresponding to residues surrounding serine 2054 of human ABCA1 was used as an immunogen. This antibody only detects ABCA1 phosphorylated at serine 2054.
Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
ABCA1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes, and are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, ABCA1 functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in this protein have been associated with Tangier's disease and familial high-density lipoprotein deficiency (1). It has been shown that Ser-1042 and Ser-2054, located in the nucleotide binding domains of ABCA1, are major phosphorylation sites for PKA. Phosphorylation of Ser-2054 within the nucleotide binding domain 2 was found to be particularly important for ApoA-I-dependent phospholipid efflux activity mediated by ABCA1 (2).
Related Pathway
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Western blot analysis on SH-SY5Y cell lysates using anti-Phospho-ABCA1 (pS2054) RabMAb. Cells were either (A) untreated (B) treated with Okadaic Acid and Calyculin A.<br>Note: Primary antibody was diluted with 1% BSA.
