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Anti-ABCA1 PHOSPHO Antibody EPR2485


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against ABCA1 (pS2054) (Phospho-specific)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 2054 of human ABCA1 was used as an immunogen. This antibody only detects ABCA1 phosphorylated at serine 2054.
Clone NameEPR2485 IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:50000 - 1:200000; ICC/IF: 1:500 - 1:1000
Predicted MW Explanation 254 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IHC-P.

Reference Data

Target NameHomo sapiens ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1)
Alternative NameABC-1; ABC1; CERP; HDLDT1; TGD
Database LinkNP_005493
Entrez Gene 19 Human
FunctionABCA1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes, and are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, ABCA1 functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in this protein have been associated with Tangier's disease and familial high-density lipoprotein deficiency (1). It has been shown that Ser-1042 and Ser-2054, located in the nucleotide binding domains of ABCA1, are major phosphorylation sites for PKA. Phosphorylation of Ser-2054 within the nucleotide binding domain 2 was found to be particularly important for ApoA-I-dependent phospholipid efflux activity mediated by ABCA1 (2).
Related PathwayTransmembraneDruggable Genome ABC transporters

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Western blot - Anti-ABCA1 (phospho S2054) antibody [EPR2485]; All lanes : Anti-ABCA1 (phospho S2054) [EPR2485] antibody at 1/50000 dilution.Lane 1 : SH-SY5Y cell lysate, untreated.Lane 2 : SH-SY5Y cell lysate, Okadaic Acid and Calyculin A treated.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.developed using the ECL technique.Predicted band size : 254 kDa.
Immunocytochemistry/ Immunofluorescence - Anti-ABCA1 (phospho S2054) antibody [EPR2485]; TA310159, at a 1/500 dilution, staining ABCA1 (green) in Okadaic Acid and Calyculin A treated SH-SY5Y cells by immunofluorescence. DNA is marked in blue.


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