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Home Antibody All anti-AAK1 antibodies

Anti-AAK1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306656
  • Rabbit Polyclonal Aak1 Antibody
100ug 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenAak1 antibody was raised against a 18 amino acid peptide near the carboxy terminus of the human Aak1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens AP2 associated kinase 1 (AAK1)
Alternative NameRP11-427H3.3
Database LinkNP_055726
Entrez Gene 22848 Human
Entrez Gene 269774 Mouse
Entrez Gene 500244 Rat
FunctionAP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxf) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesting that Aak1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its recycling back to the plasma membrane.
Related Pathway

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WB Image
Western blot analysis of Aak1 in A-20 lysate with Aak1 antibody at (A) 1 and (B) 2 µg/ml.

 

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