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Over 1000 citations of OriGene cDNA clones
Tumor cell-secreted angiogenin induces angiogenic activity of endothelial cells by suppressing miR-542-3p Cancer Lett. Nov 2015 [POU2F1]

OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo Stem Cell Research Sep 2015 [LHX2]

The presence of Estrogen Receptor ß modulates the response of breast cancer cells to therapeutic agents Int. J. Biochem. Cell Biol. Sep 2015 [ESR2]

A novel GLP-1 receptor interacting protein ATP6ap2 regulates insulin secretion in pancreatic beta cells J. Biol. Chem. Aug 2015 [ATP6AP2]

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DCLK1 (NM_004734 ) Stable Cell Line

Catalog #:SL500073Price:$12888    technical questions?
Description:Human Doublecortin-like Kinase 1 DCAMKL1 Stable Cell Line - NIH3T3
Other names: CL1; CLICK1; DCAMKL1; DCDC3A; DCLK
Host CellNIH3T3
cDNA Clone:
Format:Cryopreserved cells, 2 x 10E6 cells/vial
Mycoplasma:Negative by MycoAlert Kit, Lonza
Cell Line Validation:Western blot
Background:Doublecortin-like Kinase 1 (DCAMKL1) is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, a C-terminal serine/threonine protein kinase domain and a serine/proline-rich domain which is between the doublecortin and the protein kinase domains. Different domains reveal alterative functions. N-terminal domains bind microtubules and regulate microtubule polymerization. The C-terminal domain shows substantial homology to Ca2+/calmodulin-dependent protein kinase. However, the serine/proline-rich domain functions in mediating multiple protein-protein interactions. DCAMKL1 involves in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. DCAMKL1 expression is up-regulated by brain-derived neurotrophic factor and is associated with memory and general cognitive abilities.
Figure 1. Western blot analysis for NIH3T3/ DCAMKL1 using mAb against DDK (FLAG) tag (Cat# TA50011-100). Protein concentrations were measured by BCA kit (Thermo Scientific Inc.). Lane A: NIH3T3/ DCAMKL1 Lysate at Passage 1 from Master Cell Bank, 15 ug; Lane B: NIH3T3/ DCAMKL1 Lysate at Passage 6 from Master Cell Bank, 15 ug ; Lane C: Untransfected NIH3T3 cells Lysate was used as negative control, 15 ug.

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