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Over 1000 citations of OriGene cDNA clones
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease Nat. Genet. Jan 2016 [TRAF6]

Periostin activates pathways involved in epithelial-mesenchymal transition in adamantinomatous craniopharyngioma Journal of the Neurological Sciences Jan 2016 [POSTN]

The New Role of CD163 in the Differentiation of Bone Marrow Stromal Cells into Vascular Endothelial-Like Cells Stem Cells International Jan 2016 [HMBOX1]

a-Helix-Peptides Composing the Human Nuclear Receptor ERR? Competitively Provoke Inhibition of Functional Homomeric Dimerization Biopolymers Dec 2015 [AR]

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CNR1 (NM_016083 ) Stable Cell Line

Catalog #:SL500066Price:$12888    technical questions?
Description:Human CB1 Cannabinoid Receptor Stable cell Line - CHO-K1
Gene:CNR1
Other names: CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR
Host CellCHO-K1
cDNA Clone:
Format:Cryopreserved cells, 6 x 10E6 cells/vial
Mycoplasma:Negative by MycoAlert Kit, Lonza
Cell Line Validation:Function assay
Background:The CB1 cannabinoid receptor is expressed primarily in the brain and is a target for cannabinoids (Matsuda et al., 1990, Gerard et al., 1991), the psychoactive ingredients of marijuana. When it is activated, the CB1 receptor inhibits adenylate cyclase through Gi protein. The CB1 receptors play a significant role in modulation of food intake.
Figure 1. CB1-mediated inhibition of intracellular cAMP accumulation. CHO-K1 cells that stably express the Flag tagged hCB1 Cannabinoid receptor (blue circles) were exposed to the indicated concentrations of WIN55212-2 for 30 min at 37°C along with 10uM forskolin and 1mM IBMX. Intracellular cAMP was assayed using the HitHunter Kit (GE Healthcare). Data points represent the average +/- standard deviation of duplicate determinations.

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