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Over 1000 citations of OriGene cDNA clones
Citrullinated Vimentin Presented on MHC-II in Tumor Cells Is a Target for CD4+ T-Cell-Mediated Antitumor Immunity Cancer Res. Feb 2016 [MOG]

A short conserved motif in ALYREF directs cap-and EJC-dependent assembly of export complexes on spliced mRNAs Nucleic Acids Research Jan 2016 [ALYREF]

An integrated systems biology approach identifies positive cofactor 4 as a factor that increases reprogramming efficiency Nucleic Acids Res. Jan 2016 [SUB1]

Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain Cereb. Cortex Jan 2016 [SLC7A10]

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CNR1 (NM_016083 ) Stable Cell Line

Catalog #:SL500066Price:$12888    technical questions?
Description:Human CB1 Cannabinoid Receptor Stable cell Line - CHO-K1
Gene:CNR1
Other names: CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR
Host CellCHO-K1
cDNA Clone:
Format:Cryopreserved cells, 6 x 10E6 cells/vial
Mycoplasma:Negative by MycoAlert Kit, Lonza
Cell Line Validation:Function assay
Background:The CB1 cannabinoid receptor is expressed primarily in the brain and is a target for cannabinoids (Matsuda et al., 1990, Gerard et al., 1991), the psychoactive ingredients of marijuana. When it is activated, the CB1 receptor inhibits adenylate cyclase through Gi protein. The CB1 receptors play a significant role in modulation of food intake.
Figure 1. CB1-mediated inhibition of intracellular cAMP accumulation. CHO-K1 cells that stably express the Flag tagged hCB1 Cannabinoid receptor (blue circles) were exposed to the indicated concentrations of WIN55212-2 for 30 min at 37°C along with 10uM forskolin and 1mM IBMX. Intracellular cAMP was assayed using the HitHunter Kit (GE Healthcare). Data points represent the average +/- standard deviation of duplicate determinations.

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