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Over 1000 citations of OriGene cDNA clones
Tumor cell-secreted angiogenin induces angiogenic activity of endothelial cells by suppressing miR-542-3p Cancer Lett. Nov 2015 [POU2F1]

OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo Stem Cell Research Sep 2015 [LHX2]

The presence of Estrogen Receptor ß modulates the response of breast cancer cells to therapeutic agents Int. J. Biochem. Cell Biol. Sep 2015 [ESR2]

A novel GLP-1 receptor interacting protein ATP6ap2 regulates insulin secretion in pancreatic beta cells J. Biol. Chem. Aug 2015 [ATP6AP2]

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CNR1 (NM_016083 ) Stable Cell Line

Catalog #:SL500066Price:$12888    technical questions?
Description:Human CB1 Cannabinoid Receptor Stable cell Line - CHO-K1
Other names: CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR
Host CellCHO-K1
cDNA Clone:
Format:Cryopreserved cells, 6 x 10E6 cells/vial
Mycoplasma:Negative by MycoAlert Kit, Lonza
Cell Line Validation:Function assay
Background:The CB1 cannabinoid receptor is expressed primarily in the brain and is a target for cannabinoids (Matsuda et al., 1990, Gerard et al., 1991), the psychoactive ingredients of marijuana. When it is activated, the CB1 receptor inhibits adenylate cyclase through Gi protein. The CB1 receptors play a significant role in modulation of food intake.
Figure 1. CB1-mediated inhibition of intracellular cAMP accumulation. CHO-K1 cells that stably express the Flag tagged hCB1 Cannabinoid receptor (blue circles) were exposed to the indicated concentrations of WIN55212-2 for 30 min at 37°C along with 10uM forskolin and 1mM IBMX. Intracellular cAMP was assayed using the HitHunter Kit (GE Healthcare). Data points represent the average +/- standard deviation of duplicate determinations.

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