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Over 1000 citations of OriGene cDNA clones
Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency - molecular profiling and functional rescue Sci Rep 2017 [GRIN2A]

Aesculin modulates bone metabolism by suppressing receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and transduction signals Biochem. Biophys. Res. Commun. 2017 [TNFRSF11A]

A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5 J. Med. Chem. 2017 [CYP3A5]

Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells J. Med. Chem. 2017 [CYP1A1]

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CNR1 (NM_016083 ) Stable Cell Line

Catalog #:SL500066Price:$12888    technical questions?
Description:Human CB1 Cannabinoid Receptor Stable cell Line - CHO-K1
Gene:CNR1
Other names: CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR
Host CellCHO-K1
cDNA Clone:
Format:Cryopreserved cells, 6 x 10E6 cells/vial
Mycoplasma:Negative by MycoAlert Kit, Lonza
Cell Line Validation:Function assay
Background:The CB1 cannabinoid receptor is expressed primarily in the brain and is a target for cannabinoids (Matsuda et al., 1990, Gerard et al., 1991), the psychoactive ingredients of marijuana. When it is activated, the CB1 receptor inhibits adenylate cyclase through Gi protein. The CB1 receptors play a significant role in modulation of food intake.
Figure 1. CB1-mediated inhibition of intracellular cAMP accumulation. CHO-K1 cells that stably express the Flag tagged hCB1 Cannabinoid receptor (blue circles) were exposed to the indicated concentrations of WIN55212-2 for 30 min at 37°C along with 10uM forskolin and 1mM IBMX. Intracellular cAMP was assayed using the HitHunter Kit (GE Healthcare). Data points represent the average +/- standard deviation of duplicate determinations.

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