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Human CB1 Cannabinoid Receptor Stable cell Line - CHO-K1
CNR1 Other names: CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR
Cryopreserved cells, 6 x 10E6 cells/vial
Negative by MycoAlert Kit, Lonza
Cell Line Validation:
The CB1 cannabinoid receptor is expressed primarily in the brain and is a target for cannabinoids (Matsuda et al., 1990, Gerard et al., 1991), the psychoactive ingredients of marijuana. When it is activated, the CB1 receptor inhibits adenylate cyclase through Gi protein. The CB1 receptors play a significant role in modulation of food intake.
Figure 1. CB1-mediated inhibition of intracellular cAMP accumulation. CHO-K1 cells that stably express the Flag tagged hCB1 Cannabinoid receptor (blue circles) were exposed to the indicated concentrations of WIN55212-2 for 30 min at 37°C along with 10uM forskolin and 1mM IBMX. Intracellular cAMP was assayed using the HitHunter Kit (GE Healthcare). Data points represent the average +/- standard deviation of duplicate determinations.