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Home Recombinant Human Proteins All MTHFD2 Proteins

MTHFD2 (NM_001040409) Purified Human Protein

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Cat. No. Description Datasheet Price Availability*  
TP760045 Purified recombinant protein of Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2), nuclear gene encoding mitochondrial protein, tra, residues 103-350aa, with N-terminal HIS tag, expressed in E.Coli, 50ug, 50 µg (Larger pack size?) $199 In Stock
TA150088 Clone OTI2B5, Anti-His mouse monoclonal antibody $248 In Stock
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OriGene Data
Species:Human Expression Host:E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC203095, encoding the region(Met103-Asn350) of human MTHFD2
Tag:N-terminal HIS Predicted MW:37.895 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 100 mM Arg. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Protein Families: Druggable Genome
Protein Pathways: Glyoxylate and dicarboxylate metabolismOne carbon pool by folateMetabolic pathways
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_001035499 RefSeq Size: 2306 RefSeq ORF: 747
LocusID: 10797 Cytogenetic: 2p13.1  
Synonyms : NMDMC; NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase; methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase; methylene tetrahydrofolate dehydrogenase 2; methylenetetrahydrofolate dehydro
Summary: This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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