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Home Recombinant Human Proteins All PTCH1 Proteins

PTCH1 (NM_000264) Purified Human Protein

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Cat. No. Description Datasheet Price Availability*  
TP710156 Recombinant protein of human patched homolog 1 (Drosophila) (PTCH1), transcript variant 1b, residues 770-1027, with C-terminal DDK tag, expressed in sf9, 20ug, 20 µg (Larger pack size?) $399 In Stock
TA303124 Goat Polyclonal Antibody against PTCH $325 3-7 Days
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OriGene Data
Species:Human Expression Host:Sf9 cells
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC216999, encoding the region(Met-Arg770-Trp1027) of Homo sapiens PTCH1
Tag:C-terminal DDK Predicted MW:30.4 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Protein Families: ES Cell Differentiation/IPSTransmembraneDruggable Genome
Protein Pathways: Hedgehog signaling pathwayPathways in cancerBasal cell carcinoma
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_000255 RefSeq Size: 6825 RefSeq ORF: 4344
LocusID: 5727 Cytogenetic: 9q22.3  
Synonyms : BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11
Summary: This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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