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Home Recombinant Human Proteins All CCND1 Proteins

CCND1 (NM_053056) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP710056 Recombinant protein of human cyclin D1(CCND1),full length,with C-terminal flag tag,expressed in sf9 cells, 20 ug (Larger pack size?) $399 In Stock
TA801655 CCND1 mouse monoclonal antibody,clone 1G2 $325 In Stock
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Also for CCND1 (NM_053056)
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OriGene Data
Species:Human Expression Host:Sf9 cells
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC204957, encoding human full-length CCND1
Tag:C-terminal DDK Predicted MW:34 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 7 months from receipt of products under proper storage and handling conditions.
Protein Families: Stem cell relevant signaling - JAK/STAT signaling pathwayStem cell relevant signaling - Wnt Signaling pathwayStem cell - PluripotencyStem cell relevant signaling - DSL/Notch pathwayDruggable Genome
Protein Pathways: Cell cyclep53 signaling pathwayWnt signaling pathwayFocal adhesionJak-STAT signaling pathwayPathways in cancerMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_444284 RefSeq Size: 4304 RefSeq ORF: 888
LocusID: 595 Cytogenetic: 11q13  
Synonyms : BCL1; D11S287E; PRAD1; U21B31
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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