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Home Recombinant Human Proteins All RAF1 Proteins

RAF1 (NM_002880) Purified Human Protein

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Cat. No. Description Datasheet Price Availability*  
TP710020 Recombinant protein of human v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1),residues 30polyhistidine tag,expressed in sf9 cells., 20 ug (Larger pack size?) $399 In Stock
TA303679 Rabbit monoclonal antibody against Raf-1(Y198) $325 In Stock
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OriGene Data
Species:Human Expression Host:Sf9 cells
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC201983, encoding the region(Ser306-Phe648) of human RAF1
Tag:N-terminal HIS Predicted MW:39 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Protein Families: Protein KinaseDruggable Genome
Protein Pathways: MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwayVascular smooth muscle contractionVEGF signaling pathwayFocal adhesionMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_002873 RefSeq Size: 3245 RefSeq ORF: 1944
LocusID: 5894 Cytogenetic: 3p25.2  
Synonyms : c-Raf; CMD1NN; CRAF; NS5; Raf-1
Summary: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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