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Home Recombinant Human Proteins All MET Proteins

MET (NM_000245) Purified Human Protein

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Cat. No. Description Datasheet Price Availability*  
TP700130 Purified recombinant protein of human met proto-oncogene (hepatocyte growth factor receptor)(MET), transcript variant 2, with C-terminal DDK/His tag, expressed in human cells, 20 µg, 20 ug (Larger pack size?) $680 2-3 Weeks
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OriGene Data
Species:Human Expression Host:Human 293HEK cells
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC600030, encoding the region (Glu25-Thr932) of human MET
Tag:C-terminal DDK/HIS Predicted MW:104 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:1 x PBS, pH7.4, 10% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Protein Families: Protein KinaseTransmembraneDruggable Genome
Protein Pathways: Cytokine-cytokine receptor interactionEndocytosisAxon guidanceFocal adhesionAdherens junctionEpithelial cell signaling in Helicobacter pylori infectionMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_000236 RefSeq Size: 6641 RefSeq ORF: 2796
LocusID: 4233 Cytogenetic: 7q31.2  
Synonyms : AUTS9; c-Met; DFNB97; HGFR; RCCP2
Summary: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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