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Home Recombinant Human Proteins All PSEN1 Proteins

PSEN1 (NM_000021) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP316443 Recombinant protein of human presenilin 1 (PSEN1), transcript variant 1, 20 ug (Larger pack size?) 680 In Stock
TA313388 Rabbit polyclonal Presenilin 1 antibody $325 In Stock
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Also for PSEN1 (NM_000021)
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC216443. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:52.5 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: TransmembraneProteaseDruggable Genome
Protein Pathways: Wnt signaling pathwayNotch signaling pathwayNeurotrophin signaling pathwayAlzheimer's disease
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_000012 RefSeq Size: 2763 RefSeq ORF: 1404
LocusID: 5663 Cytogenetic: 14q24.3  
Synonyms : AD3; FAD; PS-1; PS1; S182
Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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